Vaccination against Cervical cancer - all women between 10 -45 yrs should get it.

Cervical cancer is the leading cause of death in women in India. Till now we only had screening of patients with papsmear and of late HPV ( Human Papilloma Virus)infection detection, to control the disease. The presence of a vaccine would definitely lead to a greater control of the disease.
The trick is to become vaccinated before exposure to the virus occurs. Thus earlier the better.
Glaxosmithkline has launched it's bivalent vaccine, Cervarix against Cervical cancer last month in India. Merck launched its vaccine Gardasil, a quadrivalent vaccine in India a few months back. The question now arises which vaccine to be the vaccine of choice.

1. On the face of it a quadrivalent vaccine seems to be the better choice. In reality that is not so. The vaccine protects against the HPV viruses 16,18, 6, 11, of which only the first two are responsible for cervical cancer, while the other two are responsible for genital warts.
2. On the other hand Cervarix gives protection against 16 and 18. It is better because, there is cross-reactive protection against the virus strains 45 and 31, two other viruses causing cervical cancer.
3. Cervarix is formulated with AS04, a propriety adjuvant that boosts the immune system response for a longer period of time.
4. Both vaccines are against the human papilloma virus but Cervarix seems to be more effective against cancer cervix.
   
5. Cervarix can be given to females between 10 to 45 yrs old, whereas Gardasil can be given to females between 16 to 26yrs only.
6. Both the vaccines are given in the schedule of 0,1,6 months. Cervarix is the costlier one being priced at Rs.3200 per dose.
   

Cervarix seems to win against Gardasil because of its stronger immune response and broader protection